各種drug delivery systemによるフルオレセインの角膜と前房内移行

Transfer of fluorescein into the cornea and anterior chamber by various drug delivery systems

　0.5％フルオレセイン水溶液を1時間浸潤させた高含水（A群），低含水ソフトコンタクトレンズ（B群）およびコラーゲンシールド（C群）を6名の男性に短時間装用させ，角膜，前房内フルオレセイン濃度の時間変化を，点眼（D群）の場合と比較した。3時間後の前房内濃度は，A群425.4±217.0ng／ml,B群193.2±129.3ng／ml，C群81.0±35.2ng／ml,D群3.3±1.7ng／mlでありB, C群間以外の各群で有意差（p＜0.05）を認めた。角膜内濃度も同様であった。このように，短時間装用の場合フルオレセインのdrug deliv—ery systemとしては，高含水ソフトコンタクトレンズが最良であった。

We quantitated the corneal and aqueous concen-trations of fluorescein in 6 male volunteers who were asked to wear, for 2 minutes each, high- and low-water content soft contact lens and collagen shield, all of which were presoaked in 0.5% fluores-cein for 60 minutes. They also received fluorescein as eyedrops. The aqueous concentration after 3 hours was highest after wearing high-water con-tent soft contact lens to decrease in the above order. The differences were significant except between low-water soft contact lens and collagen shield. Findings were essentially the same for the corneal concentration. We conclude that soft con-tact lens with high water content is most useful as delivery system of fluorescein with short-time wear.