BSS PLUS®灌流によるIOL移植眼の前房蛋白濃度の術後経過について

Effect of BSS PLUS® on changes in aqueous protein concentration after phacoemulsification and posterior intraocular lens implantation

　酸化型グルタチオンを含む房水組成溶液（BSS PLUS^®）をKPE・IOL手術の眼内灌流液として使用し，前房蛋自濃度をレーザーフレアセルメーターを用いて測定し，血腋房水柵に及ぼす影響をOPEGUARD^®-MAと比較検討した。BSS PLUS^®を使用した188眼の前房蛋白濃度は，OPEGUARD^®-MAを使用した115眼のそれより低い値を示した。BSS PLUS^®を使用した症例中，糖尿病眼および眼内レンズがout of thebagに固定された症例の前房蛋白濃度は，非糖尿病眼・眼内レンズがin the bagに固定された症例のそれとほぼ同様の値を示した。BSS PLUS^®は血液房水柵の破壊をきたしやすい症例で，眼組織の保護作用が高い灌流液であると推定された。

To examine the effect of BSS PLUS^® as compared with OPEGUARD^®-MA, we evaluated aqueous protein concentration via Laser Flare-Cell Meter following phacoemulsification (KPE) and IOL implantation. Used as the basis of thin study were 303 eyes. KPE and IOL implantation was performed on 188 eyes by using BSS PLUS^®, and on 115 eyes by using OPEGUARD^®-MA. The aqueous protein concentration in the cases of using BSS PLUS^® (32 eyes) were lower than that in the cases of using OPEGUARD^®-MA (28 eyes) in the diabetic eyes until seven days after surgery. In cases with IOL fixed out of the capsular bag (44eyes), the concentration in the 16 eyes using BSS PLUS^® were lower than in the 28 eyes using OPEGUARD^®-MA, until seven days after surgery. In the cases requiring more than 0.73mJ ultrasonic energy (112 eyes), the concentration in the 61 eyes using BSS PLUS^® were lower than in the 51 eyes using OPEGUARD^®-MA at only one day after surgery. Of the 188 eyes using BSS PLUS^®, the concentration in the diabetic eyes (32 eyes) were generally equal to that in the non-diabetic eyes (156 eyes). These results indicated that BSSPLUS^® had less influence on damage to the blood aque-ous barrier than OPEGUARD^®-MA, the availabil-ity and security of BSSPLUS^® was confirmed as intraocular irrigating solution.