糖尿病と前房蛋白濃度—2．光凝固の影響および左右眼の前房蛋白濃度の関係

Aqueous protein concentration in diabetics Report:2. Laterality in protein concentration and effect of photocoagulation

　糖尿病患者122人244眼を対象として，フレアー・セルメーターによる前房蛋白濃度の検討を行った。既報同様に網膜症病期（福田分類）と前房蛋白濃度の間に有意の相関関係を認めた。良性網膜症期52例の左右眼の前房蛋白濃度は，網膜症の病期が同じ場合左右差が少なく，両者間に有意の相関（r＝0.926, P＜0.001）を認めた。網膜光凝固術を施行した22眼について前房蛋白濃度を経時的に測定したところ，光凝固術直後に一時的な上昇を示し，その後低下した。しかし，術後の値は術前の値より高値を示す例が多かった。

We quantitated the protein concentration in the aqueous humor in 244 eyes of 122 patients with diabetes using a laser flare-cell meter. There was a significant correlation between the protein concen-tration in the aqueous and the severity of diabeticretinopathy as graded after Fukuda's classification. We assessed the correlation of protein concentra-tion in the aqueous between the right and left eye in 52 patients with nonproliferative retinopathy. Val-ues for both eyes showed a good linear correlation (r= 0.926, p＜0.001). We evaluated the effect of argon laser photocoagulation in 22 eyes with pre-proliferative retinopathy. We noted significant and marked increases in protein concentration at 1 week after photocoagulation. The values remained elevated over the pretreatment level during the ensuing 6-month period with a gradual tendency to decrease.