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Diclofenac sodium ophthalmic solution before and after cataract surgery Hiroshi Kitaoji 1 , Yoshihide Nakai 1 , Setsuko Kitaoji 1 1Tokai Eye Clinic pp.171-174
Published Date 1991/2/15
DOI https://doi.org/10.11477/mf.1410908297
  • Abstract
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We evaluated the effect of 0.1% diclofenac sodium ophthalmic solution before and after cata-ract surgery with posterior chamber lens implanta-tion. Out of a total of 264 eyes, 208 eyes were treated by topical diclofenac sodium and 46 by topical indomethacin in oil. The remaining 10 eyes served as control.

Eyes treated by diclofenac or indomethacin manifested lesser fibrin exudate during the pos-toperative 2 weeks. Both agents resulted in occa-sional corneal erosion or diffuse superficial ker-atitis. Latent epithelial damage was detected in diclofenac-treated group by specular microscopy. In diclofenac-treated group, the postoperative epithelial damage was inversely correlated with the preoperative endothelial cell density (p<0.01). As an overall appraisal, aqueous ophthalmic solution of diclofenac was effective and was better tolerated than indomethacin.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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