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Ocular manifestations in a case of subacute sclerosing panencephalitis Toyokazu Okami 1 , Nobuko Kishimofo 1 , Masami Uehara 1 , Hiroyuki Matsuo 2 , Yasurou Kasubuchi 2 1Dept of Ophthalmol, Matsushita Memorial Hosp 2Dept of Pediatr, Matsushita Memorial Hosp pp.747-751
Published Date 1990/5/15
DOI https://doi.org/10.11477/mf.1410908161
  • Abstract
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A 10-year-old girl presented with blurring of vision in her right eye of recent onset. During the ensuing 2 months, she manifested typical neur-ological signs of subacute sclerosing panence-phalitis (SSPE). Elevated titers for measles anti-body were present in the serum and the cere-brospinal fluid.

The fundus changes included edema and hemor-rhage in the macula and yellowish white exudation in the peripheral retina in the right eye. Fluorescein angiography showed diffuse hyperfluorescence inthe affected areas. The macular lesion turned into atrophic chorioretinal scar with clumps of pigment granules and retinal folds 4 months later. Similar exudative lesion appeared in the posterior fundus in the left eye.

During the course of the disease, she manifested abnormal ocular movements and myoclonus. Electrooculogram showed slow movement of both eyes to the lateral position, followed by rapid return to the primary position. These movements were synchronous with periodic synchronous dis-charge in EEG.

The present case indicates that ocular manifesta-tions may precede typical neurological symptoms of SSPE.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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