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Two cases of leukemia with ocular involvement Yuji Ohshita 1,2 , Toshio Kodama 2 , Atsushi Suzuki 2 , Haruhiko Torikai 2 , Yuichi Ohashi 2 , Meguru Urabe 3 , Tetsuhiko Nomura 3 1Masaoka Eye Clinic 2Dept of Ophthalmol, Sch of Med, Ehime Univ 31st Dept of Internal Med, Sch of Med, Ehime Univ pp.987-992
Published Date 2002/6/15
DOI https://doi.org/10.11477/mf.1410907769
  • Abstract
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We observed two cases of ocular infiltration of leukemia cells. A 59-year-old man presented with severe uveitis and hypopyon in both eyes. He had been diagnosed with adult T-cell leukemia/lymphoma (ATLL) 4 months before. Topical and systemic corticosteroid failed to influence the eye findings. Biopsy of anterior chamber showed atypical lymphocytes typical for ATLL as well as DNA fragments of human T-cell leukemia virus type I by polyme-rase chain reaction (PCR). The uveitis subsided after chemotherapy and radiation totalling 30 Gy. Another 71-year-old man presented with acute visual loss in his right eye. He had been diagnosed with acute myeloblastic leukemia (AML) 22 months before. Funduscopy showed papilledema in the right eye. Magnetic resonance imaging (MRI) showed swollen right optic nerve and led to the diagnosis of infiltrative optic neuropathy. No radiation was performed as the patient was staying in a sterile room for septicemia. His visual acuity decreased to no light perception 2 months later. These cases illustrate that the visual prognosis in patients of leukemia with ocular infiltration may be decided by the availability of radiation in addition to chemotherapy.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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