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Two cases of orbital chronic lymphocytic leukemia/small lymphocytic lymphoma Ryotaro Noda 1 , Toshio Kodama 1 , Yoshika Ogawa 1 , Soichiro Tahara 1 , Takeshi Joko 1 , Yumi Oshiro 2 1Department of Ophthalmology, Matsuyama Red Cross Hospital 2Department of Pathology, Matsuyama Red Cross Hospital pp.269-276
Published Date 2020/3/15
DOI https://doi.org/10.11477/mf.1410213489
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Abstract Purpose:Chronic lymphocytic leukemia(CLL)is characterized by peripheral blood B-cell lymphocytosis and small lymphocytic lymphoma(SLL)is diagnosed on the presence of lymphadenopathy. Both of CLL and SLL are clonal B cell lymphoid malignancies and they are considered the same entity as CLL/SLL. We report the two cases of orbital CLL/SLL.

Cases and Findings:Case 1 was a 78-year old male who was diagnosed as CLL and presented with masses underneath the lower eyelids. Lymphocyte count was 18,452/μl and orbital imaging showed bilateral orbital tumors and the splenomegaly. Histological examination of extracted tumors showed an infiltration of small lymphocytes without atypia that stained positive for CD5 and CD23, consistent with CLL/SLL. Two years after the tumor extraction, no recurrence was observed. Case 2 was 62-year old male referred to us for swelling of the left upper eyelid. Lymphocyte count was 8,789/μl and the extracted tumor showed infiltration of small lymphocytes which were immunopositive for CD5 and CD23. Pathologic diagnosis was CLL/SLL. Since the residual orbital tumor, splenomegaly and the swollen cervical lymph node were detected, ibrutinib was administered and the size of orbital tumor decreased dramatically.

Conclusion:Immuno-phenotyping markers were helpful in the diagnosis of CLL/SLL and the two cases revealed the indolent course of malignant lymphoma.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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