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(P-1-114) 78歳の女性が,17か月前からの左眼視力低下で受診した。左眼の視力は,0.06×10.0Dであった。眼底には後部ぶどう腫とその範囲に一致する網膜剥離,黄斑円孔があった。手術中に除去した網膜前膜を除去し,病理的に検索した。ヘマトキシリン・エオジン染色では,主にエオジン好性の薄い線維絹織から成り,細胞成分を含んでいた。この線維成分を主体とする層は,Massonの膠原線維染色で膠原線維であると同定された。抗glial fibrillary acidic protein (GFAP)抗体による免疫組織化学染色で,細胞成分に富んだ層はGFAP陽性であった。以上の所見は特発性黄斑円孔のそれと同様であった。網膜前膜は硝子体膠原線維に由来し,網膜のグリア増殖で修飾されたと推定した。
A 78-year-old female presented with impaired visual acuity in her left eye since 17 months before. The visual acuity was 0.06 corrected with -10.0 diopters. Funduscopy showed posterior staphyloma, macular hole and serous retinal detachment in the area of staphyloma. During surgery, the epiretinal membrane was removed and was subjected to histochemical studies. By hematoxilin - eosin staining,the membrane consisted of thin fibrous tissue and partially of thickened cellular tissue. Masson trichrome stain showed the fibrous layer to consist of collaenous matrix. The cellular layer was positively stained by anti-glial fibrillary acidic protein (GFAP) . The findings were similar to those of idiopathic macular hole. It appeared that the membrane originated from vitreous collagen and was modified by retinal glial cell proliferation.
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