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Remission of progressive multifocal leukoencephalopathy following highly active antiretroviral therapy Shigetoshi Nagataki 1 , Shigeko Yashiro 1 , Nobutaka Sato 1 , Natsuo Tachikawa 2 , Yoshimi Kikuchi 2 , Akira Yasuoka 2 , Sinichi Oka 2 1Dept of Ophthalmol, International Med Center of Japan 2Dept of AIDS Clinical Center, International Med Center of Japan pp.1793-1797
Published Date 1999/10/15
DOI https://doi.org/10.11477/mf.1410906627
  • Abstract
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A 40-year-old male with hemophilia had been diagnosed to be infected by human immunodeficiency virus 12 years before. He had been treated with systemic nucleoside reverse transcriptase inhibitor. Since 18 months before, he received a combination of two nucleoside and one non-nucleoside reverse transcriptase inhibitors. One month later, he developed right homonymous hemianopia. His visual acuity was normal. Magnetic resonance imaging (MRI) showed T2- prolonged lesion in the white matter in bilalateral occipital lobes without contrast enhancing or mass effect. The findings were suggestive of progressive multifocal leukoencephalopathy. He was treated by highly active antiretroviral therapy, a combination of two nucleoside reverse transcriptase inhibitors and a protease inhibitor. Four weeks later, the hemianopia decreased in size and repeated MRI showed improvement in the T2-prolonged lesion. His brain lesion is now considered to be in a state of remission.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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