Ultrastructure of subretinal proliferative tissue obtained by vitrectomy Toshihiko Kohno 1 , Hajime Inomata 1 , Toshihiro Kono 2 , Kenji Ohshima 2 1Dept of Ophthalmol, Fac of Med, Kyushu Univ 2Dept of Ophthalmol, Sch of Med, Fukuoka Univ pp.257-261
Published Date 1992/3/15
DOI https://doi.org/10.11477/mf.1410901029
  • Abstract
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We removed subretinal proliferative tissue in 12 eyes during vitreous surgery. Retinal detachment was present in all the eyes secondary to blunt trauma, retinopathy of prematurity, giant tear, diabetic retinopathy or idiopathic vitreous hemor-rhage. The light microscopic features varied from loose reticular structure to densely condensed strands. The subretinal tissue contained cells simulating macrophages, fibroblasts, epithelial cells and spindle-shaped ones. These cells weredefined as retinal pigment apithelial cells in 10 eyes.The tissue also contained fibrin and collagen as components. There were 4 eyes manifesting retinal pigment epithelial cells simulating macrophages or spindle cells and embedded in loose reticular struc-tures of fibrin. This tissue type appeared to be early manifestations of subretinal proliferation. The find-ings led to the hypothesis that fibrin is the primary component of subretinal proliferative tissue and that retinal pigment epithelial cells secondarily proliferate along the fibrinous tissue as scaffold.

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