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A case of orbital MALT lymphoma complicated by Sjögren syndrome Akari Arakawa 1 , Hiromi Matsunaga 1 , Ken Kuriki 2 , Yasutaka Kojima 3 , Yoshiro Otsuki 4 1Department of Ophthalmology, Yaizu City Hospital 2Department of Diagnostic Pathology, Yaizu City Hospital 3Department of Oculoplastic and Orbital surgery, Seirei Hamamatsu General Hospital 4Department of Pathology, Seirei Hamamatsu General Hospital pp.527-532
Published Date 2023/4/15
DOI https://doi.org/10.11477/mf.1410214774
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Abstract Purpose:To report a case of orbital mucosa-associated lymphoid tissue(MALT)lymphoma complicated by Sjögren syndrome in a patient with a history of orbital MALT lymphoma of the contralateral orbit.

Case:A 78-year-old female with a history of left oribital MALT lymphoma presented with diplopia six months ago. Pathohistological examination of the lymphoma tissue showed immunoglobulin G positivity and clonality of the κchain, and the patient received radiotherapy prior to presentation.

Findings:Corrected visual acuity was 1.0 in the right and 1.0 in the left eye. The right eye showed exotropia of approximately 15°, accompanied by exophthalmos and restricted abduction. Imaging revealed a right orbital tumor. Histopathological evaluation of the biopsy specimens from the tumor confirmed MALT lymphoma, similar to the earlier findings. The patient was diagnosed with relapse of MALT lymphoma of the contralateral orbit and underwent radiotherapy, which reduced diplopia. She is currently doing well. The patient had experienced dry eyes before treatment;evaluation confirmed the diagnosis of Sjögren syndrome.

Conclusion:Chronic inflammatory conditions, such as autoimmune diseases and infection, are implicated as etiopathogenetic contributors to MALT lymphoma. Reportedly, Sjögren syndrome is a risk factor for lymphoma. This case report highlights the importance of careful evaluation, in terms of time and space, to detect a history of preexisting diseases.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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