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One-year outcome of omidenepag isopropyl in primary open angle glaucoma and preperimetric glaucoma Hiroaki Ozaki 1 , Ayaka Kobayashi 1 , Yoko Yokoo 2 , Hirohiko Kato 3 , Keiko Ozaki 4 , Eiichi Uchio 1 1Department of Ophthalmology, Faculty of Medicine, Fukuoka University 2Department of Ophthalmology, Fukuoka Tokushukai Hospital 3Kato Eye Clinic 4Ozaki Eye Clinic pp.1380-1386
Published Date 2022/10/15
DOI https://doi.org/10.11477/mf.1410214527
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Abstract Purpose:To investigate the 1-year outcome of selective prostagrandin E2 receptor agonist, omidenepag isopropyl ophthalmic solution 0.002%(OMDI)usage in initial treatment and switching from conventional prostaglandin F2α to OMDI for primary open angle glaucoma.

Materials and methods:One hundred two eyes of 102 patients who received OMDI for one year were assessed. The subjects were comprised of 33 men and 69 women. The average age was 65.2±13.0 years. The classification involved 77 cases of normal tension glaucoma, 17 cases of primary open angle glaucoma, and 8 cases of preperimetric glaucoma. OMDI was administered as an initial treatment in 75 patients and was switched from prostaglandin F2α in 27 patients. The IOP lowering effect visual field defects and the adverse effects were assessed.

Results:As an initial treatment, the average IOP was 14.1±3.9 mmHg before treatment. It lowered to 11.6±2.9 mmHg at 6 months, and 11.8±3.1 mmHg at 1 year respectively. When we switched the prostaglandins to the OMDI, the average IOP was 12.3±2.2 mmHg before switching and resulted in 12.1±2.0 mmHg at 1 year, which was no different. The adverse effect of conjunctival injection occured in 5 cases, whereas iridocyclitis, macular edema, and pigmentation of the iris were not observed in any cases over time. There were 26(34.7%)non-responder patients after initial treatment.

Conclusions:OMDI reduced IOP for 1 year in patients with open angle glaucoma and preperimetric glaucoma after initial treatment. Additionally, OMDI showed equivalent IOP lowering effect when switched to from conventional prostaglandin F2α;thus, it was just maintained. No perioribital adverse effects were found during the follow-up period.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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