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A case of IgG4-related ophthalmic disease involving the conjunctiva Kei Nakayama 1 , Satoru Joko 1 , Masashi Kitani 2 1Department of Ophthalmology, National Hospital Organization Tokyo National Hospital 2Department of Pathology, National Hospital Organization Tokyo National Hospital pp.613-616
Published Date 2022/5/15
DOI https://doi.org/10.11477/mf.1410214376
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Abstract Purpose:To report a case of conjunctival tumor in IgG4-related disease.

Case:The patient was a 61-year-old woman. She was diagnosed with asthma and eosinophilic sinusitis.

Findings and clinical courses:Three months ago, she became aware of a conjunctival tumor. A large mass was found in the upper right bulbar conjunctiva. Computed tomography demonstrated swelling of the right extraocular muscles and lacrimal gland. Serum IgG4 level was elevated. As this lesion did not improve with eye drop therapy, we performed a surgical resection. Histopathologically, there were no malignant findings. Plasmacytes were positive for IgG, and over 50% of these cells were positive for IgG4. Based on these histopathological and serological findings, this case was diagnosed as an IgG4-related ophthalmic disease. Systemic administration of predonisolone was started. After the resection, there was no recurrence of the conjunctival mass for seventeen months.

Conclusion:We report a case of conjunctival tumor in an IgG4-related disease in which surgical resection was performed as it did not respond to eye drop therapy.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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