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One year outcome of combined photodynamic theraphy and aflibercept for polypoidal choroidal vasculopathy Yuki Kozawa 1 , Takashi Hiroe 1 , Yuichirou Tanaka 1 , Genichirou Kishino 1 , Jun Kobayashi 1 , Kazushige Toda 1 , Tadahiko Kozawa 1 1Kozawa Eye Internal Medicine Hospital pp.1079-1086
Published Date 2021/8/15
DOI https://doi.org/10.11477/mf.1410214071
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Abstract Purpose:This study aimed to report the one-year outcome of combination therapy with intravitreal aflibercept(IVA)and photodynamic therapy(PDT)using a modified treat-and-extend(mTAE)regimen for polypoidal choroidal vasculopathy(PCV).

Cases and method:Eleven eyes with treatment-naïve PCV treated with IVA plus PDT using an mTAE regimen for 1 year between April 2019 and March 2020 were retrospectively reviewed.

 We assessed best-corrected visual acuity(BCVA), central foveal thickness(CFT), central choroidal thickness(CCT), and the number of IVA treatments over 1 year.

 All patients received three consecutive monthly IVA treatments as loading phase, and PDT was performed 2 days after the first IVA.

 During the maintenance phase, the patients were treated using an mTAE regimen.

 The injection interval was extended by 4 weeks if there were no exudative changes, or shortened by 4 weeks if any exudative changes were seen. The maximum treatment interval was 12 weeks.

Results:The mean BCVA improved significantly from 0.32±0.12 at baseline to 0.11±0.10 at 1 year(p<0.01). The mean CFT decreased significantly from 377±48 μm at baseline to 172±11 μm at 1 year(p<0.01), while the mean CCT also significantly decreased from 249±33 μm at baseline to 209±38 μm at 1 year(p<0.05). The mean number of IVA treatments was 3.5(3-6)during treatments 1 year. Most(82%)of the patients did not require additional IVA treatments during the maintenance phase.

Conclusion:In this study, combination therapy with IVA and PDT using an mTAE regimen appeared to be effective for patients with treatment-naïve PCV. This therpy may reduce the number of injections compared to conventional TAE.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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