雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Prescriptions and short-term efficacy of brimonidine/timolol fixed combination Ryoko Komori 1 , Kenji Inoue 1 , Shiho Kunimatsu-Sanuki 2 , Kyoko Ishida 3 , Goji Tomita 1,3 1Inouye Eye Hospital 2Nishikasai Inouye Eye Hospital 3Department of Ophthalmology, Toho University Ohashi Medical Center pp.521-526
Published Date 2021/4/15
DOI https://doi.org/10.11477/mf.1410213966
  • Abstract
  • Look Inside
  • Reference

Abstract Purpose:Brimonidine/timolol fixed combination(BTFC)is newly available. In this study, the characteristics and short-term efficacy in patients prescribed with BTFC were retrospectively investigated.

Subjects and methods:The subjects were 64 patients newly administered with BTFC at the Inouye Eye Hospital from December 2019 to July 2020. The patients' characteristics were investigated. They were classified into the adding(BTFC to the previous medications)or switching(to BTFC from the previous medications)group. Intraocular pressure(IOP)values before and after the switching were compared in the switching group.

Results:The patients were 31 men and 33 women, and the mean age was 68.7±11.0. The diagnoses were primary open-angle glaucoma in 43 patients, secondary glaucoma in 13 patients, and others. The mean IOP value was 16.9±5.2 mmHg and the mean number of medications was 3.6±1.4. Four patients were in the adding group and 60 patients were in the switching group. In the switching group, 32 patients(Group A)switched from the combination therapy with brinzolamide/timolol fixed combination and brimonidine to the combination therapy with BTFC and brinzolamide;11 patients(Group B)switched from β-blockers;and 5 patients switched from brimonidine. IOP in A Group was not significantly different before and after switching(16.6±4.3 and 16.7±4.6 mmHg, respectively), but IOP in B Group had significantly decreased after switching(15.8±3.2 and 14.4±2.8 mmHg, respectively. p<0.05).

Conclusions:BTFC is used with high frequency in patients switched between the same ingredients or patients switched from β-blockers or brimonidine. There was no difference in IOP in the switching of medications between the same ingredients. The efficacy of IOP-lowering was satisfactory.


Copyright © 2021, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

関連文献

もっと見る

文献を共有