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Prescription patterns, short-term efficacy and safety of omidenepag eye drops Natsuko Shibata 1 , Kenji Inoue 1 , Shiho Kunimatsu-Sanuki 2 , Junji Inoue 2 , Norie Nozaki 3 , Kyoko Ishida 4 , Goji Tomita 4 1Inouye Eye Hospital 2Nishikasai-Inouye Eye Hospital 3Omiya Inouye Eye Clinic 4Department of Ophthalmology, Toho University Ohashi Medical Center pp.1039-1044
Published Date 2020/8/15
DOI https://doi.org/10.11477/mf.1410213653
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Abstract Purpose:We retrospectively investigated characteristics, short-term efficacy of intraocular pressure(IOP)lowering, and safety in cases who were administered omidenepag isopropyl.

Methods:A total of 133 eyes of 133 patients with glaucoma or ocular hypertension who were administered omidenepag isopropyl between December 2018 and March 2019 were enrolled. Prescription patterns, types of glaucoma, IOP at baseline, visual field defects(mean deviation value), previous medications were investigated. IOP at baseline and at 1 month after administration were compared. Adverse reactions and dropouts were investigated.

Results:Prescription patterns were switching from other medications in 77, a new administration in 50, additional administration to other medications in 6. There were 94 patients with normal-tension glaucoma, 32 patients with primary open-angle glaucoma, etc. The mean value of IOP at baseline was 16.4±5.0 mmHg, the mean deviation value was −5.53±5.35 dB, and previous medications in patients who switched from other medications were prostaglandin(PG)analogs in 58 and others. Reasons for switching from PG analogs were adverse reactions in 32, insufficient IOP lowering effects in 18, and others. Normal-tension glaucoma was the largest number of types of glaucoma(43 patients)in the new administration cases. IOP before and after administration was not different significantly in the switching cases and significantly decreased in the new administration cases. Adverse reactions were observed in 7 patients(5.3%), and the largest number of adverse reactions was conjunctival hyperemia. 6 patients(4.5%)discontinued the administration.

Conclusion:There were many patients who switched to omidenepag isopropyl from PG analogs because of adverse reactions and who were administered omidenepag isopropyl newly with normal-tension glaucoma. Short-term efficacy of IOP-lowering and safety were satisfactory.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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