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Japanese

One-year outcome of additional treatment with photodynamic therapy for age-related macular degeneration resistant to intravitreal aflibercept Yuki Kawasaki 1 , Kohei Ueda 1 , Keiko Azuma 1 , Tatsuya Inoue 1,2 , Ryo Obata 1 1Division of Ophthalmology and Visual Science, The University of Tokyo Hospital 2Department of Ophthalmology, Yokohama City University Medical Center pp.1259-1264
Published Date 2020/10/15
DOI https://doi.org/10.11477/mf.1410213705
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Abstract Purpose:To investigate one-year results of verteporfin photodynamic therapy(PDT)combined with anti-vascular endothelial growth factor(VEGF)agents for neovascular age-related macular degeneration(AMD)with limited response to aflibercept.

Patients and Methods:Medical charts of 22 eyes of 22 patients(17 men and 5 women)with neovascular AMD who were treated with PDT combined with aflibercept for recurrent or persistent disease activity after repetitive administration of aflibercept and followed at least one year were retrospectively reviewed.

Results:The mean age was 74.7±7.1 years. The mean BCVA was similar between the baseline and 1 year after combined PDT. Central foveal thickness and central choroidal thickness measured by optical coherence tomography significantly decreased at 1 year. 72.7% of the cases showed dry macula at one year. In 15 cases treated with pro re nata protocol, mean additional treatment number was 1.6±1.9, and in 7 cases treated with treat and extend protocol, mean additional treatment number was 7.3±2.3. Additional PDT was performed in 2 of 22 cases.

Conclusion:Although the effects may vary with each patient, PDT combined with anti-VEGF agents might be an option for patients after repetitive anti-VEGF treatment.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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