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Japanese

Optical coherence tomographic angiography images in polypoid choroidal vasculopathy before and after anti-VEGF treatment Kaito Yokota 1 , Masayuki Ohnaka 1 , Tomoyuki Chihara 1 , Motoki Kimura 1 , Yoshimi Nagai 1 , Kanji Takahashi 1 1Department of Ophthalmology, Kansai Medical University pp.1143-1151
Published Date 2019/9/15
DOI https://doi.org/10.11477/mf.1410213257
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Abstract Purpose:In any treatment regimen with anti-vascular endothelial growth factor(VEGF)therapy for exudative age-related macular degeneration(AMD), it is important to detect early sign of recurrence during the maintenance phase. The purpose of this study is to find out optical coherence tomography angiography(OCTA)findings that can predict a recurrence of exudation in polypoidal choroidal vasculopathy(PCV).

Cases and Methods:Of the eyes with exudative findings reappeared after an initial loading dose of 3 monthly intravitreal injection of aflibercept(IVA)for treatment naïve patients with PCV, 4 eyes in which OCTA were taken one month before recurrence of exudation were evaluated. En face OCTA images were compared before and after induction phase and at time of recurrence.

Results:All the 4 eyes showed changes in blood flow signal before recurrence of exudative findings. In 2 eyes, in which exudative findings reappeared 5 months after the first IVA, tiny vessels in abnormal vascular network were detected one month before recurrence, and in one of them a blood flow signal of polypoidal lesion that disappeared after induction therapy reappeared. In another eye, in which exudative findings reappeared 6 months after the first IVA, tiny vessels in abnormal vascular network and an increase in signal intensity of polypoidal lesion were detected 5 months after the first IVA. In the other eye, in which exudative findings reappeared 8 months after the first IVA, tiny vessels in abnormal vascular network were detected 7 months after the first IVA.

Conclusion:On en face OCTA images, tiny vessels in abnormal vascular network were detected before recurrence of exudative findings after induction anti-VEGF therapy for PCV. By taking OCTA frequently and paying attention to changes in a blood flow signal, it might be possible to predict recurrence of exudative findings in PCV.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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