Rinsho Ganka Volume 72, Issue 6 (June 2018)
Japanese

The level of vascular endothelial growth factor(VEGF)in the aqueous humor in two cases of neovascular glaucoma secondary to uveitis Yuki Maekawa 1 , Yuki Hara 1,2 , Makiko Matsumoto 1 , Eiko Tsuiki 1 , Takeshi Kumagami 1 , Takashi Kitaoka 1 1Department of Ophthalmology, Nagasaki University Hospital 2Department of Ophthalmology, Sasebo City General Hospital pp.787-793
Published Date 2018/6/15
DOI https://doi.org/10.11477/mf.1410212716
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Abstract Purpose:To report the level of vascular endothelial growth factor(VEGF)in the aqueous humor and the clinical courses in two cases of neovascular glaucoma secondary to uveitis.

Cases:Both were females aged 55 and 69 years respectively. One had repeated episodes of uveitis over a period of 18 months. The left eye showed rubeosis in the iris, posterior synechia, and signs of iritis. A fluorescein angiography did not show retinal ischemia. The second case showed intraocular pressure of 58 mmHg on the initial visit. The right eye showed neovascularization in the iris and chamber angle, with multiple chorioretinal atrophic foci. A fluorescein angiography did not show retinal ischemia. Both cases were treated by medication and intravitreal bevacizumab(IVB).

Results:The initial level of VEGF in the aqueous humor was 1,220 and 1,080 pg/ml respectively. IVB was quickly led to a regression of rubeosis. There were no hemorrhagic complications during the perioperative period.

Conclusion:An elevated level of VEGF was present in the aqueous humor in 2 eyes of uveitis with rubeosis IVB quickly led to a regression of rubeosis with no hemorrhagic complications.


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基本情報

03705579.72.6.jpg
臨床眼科
72巻6号 (2018年6月)
電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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