Clinical features of acquired ocular toxoplasmosis Ryosuke Matsushima 1 , Keiko Oh-i 1 , Hiroshi Goto 1 1Department of Ophthalmology, Tokyo Medical University Hospital pp.513-518
Published Date 2018/4/15
DOI https://doi.org/10.11477/mf.1410212655
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Abstract Purpose:To report the clinical features of acquired ocular toxoplasmosis.

Cases and Method:This retrospective study was made on 28 eyes of 24 patients who were diagnosed with acquired ocular toxoplasmosis by us in the past 21 years. The series comprised 12 males and 12 females. The age averaged 51.6±12.5 years.

Findings:Fundus lesions were located in the posterior fundus in 18 eyes. Peripapillary lesion chatracteristic for Edmund-Jensen type was present in 2 eyes only. Fluorescein angiography was performed in 20 eyes. Black center with ring-shaped hyperfluoscence was present in 10 eyes(50%). Serum level of IgM against toxoplasma was positive in 9(50%)out of 18 measured cases. Ten cases were treated by systemic acetylspiramycin alone and 7 patients with additional corticosteroid. Two patients received clindamycin alone and 4 cases were treated by other medications. During follow-up, 22 eyes showed no relapse. Two eyes showed single relapse, one eye showed 2 relapses, and 3 eyes showed 3 relapses. Best corrected visual acuity remained unchanged before and after treatment. It was 0.8 or better in 15 eyes(58%)at the final evaluation.

Conclusion:Acquired ocular toxoplasmosis responded well to treatment despite relapse in a few cases. Increase in serum toxoplasmosis IgM level is important but not essential in the diagnosis.

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