レバミピド懸濁点眼長期使用例の検討

Long-term outcome of treatment with rebamipide ophthalmic solution

要約　目的：レバミピド懸濁点眼を長期使用した症例の臨床経過の報告。

対象と方法：1年以上レバミピド懸濁点眼を続行したドライアイ症例15例27眼を対象とした。点状表層角膜症の程度を，area density（AD）分類で評価した。

結果：点眼開始後1か月後の平均点眼本数は1日4本であったが，最終時（平均979日）は1日平均2.2本であった。点眼治療開始前と比べ有意な改善がみられたが（p＜0.0001），点眼1か月と最終時の結果には有意差はなく，点眼回数の減少による治療効果の減少はなかった。

結論：点状表層角膜症に対するレバミピド懸濁点眼は，長期点眼の場合，1日2回の点眼回数でも治療効果がある。

Abstract　Purpose: To report the long-term outcome of treatment with rebamipide ophthalmic solution for dry eye with superficial punctate keratopathy.

Cases and Method: This study was made on 27 eyes of 15 cases with superficial punctate keratopathy. The series comprised one male and 14 females. The age ranged from 25 to 80 years, average 61 years. Allergic conjunctivitis was present in 7 eyes. Cases were treated by instillation of rebamipide ophthalmic solution. Severity of superficial punctate keratopathy was evaluated in terms of score based on area density classification.

Results: Treatment was continued for 664 to 1,135 days, average 979 days. Frequency of instillation averaged 4 times daily during the initial one month and 2.2 times daily during the whole period of treatment. Area density score improved significantly after one month of treatment（p＜0.0001）. There was no change in area density score after one month or longer.

Conclusion: Instillation of rebamipide ophthalmic solution was effective for superficial punctate keratopathy over prolonged period. Instillation of 4 and 2 times daily was effective as short-term and long-term treatment respectively.