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A case of herpes simplex virus corneal endotheliitis guided by quantitative polymerase chain reaction in the diagnosis and treatment Yukiko Shiraki 1 , Ayumu Manabe 1 , Jun Shoji 1 , Tohru Sakimoto 1 1Div of Ophthalmol, Dept of Vis Sci, Nihon Univ Sch of Med pp.677-681
Published Date 2015/5/15
DOI https://doi.org/10.11477/mf.1410211331
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Abstract. Purpose:To report a case of herpes simplex virus(HSV)corneal endotheliitis guided by polymerase chain reaction(PCR)of the aqueous in the diagnosis and treatment. Case:A 70-year-old male presented with recurrent corneal edema and elevated intraocular pressure in the right eye. Findings:The right eye showed severe stromal edema involving the temporal sector of the cornea, leading to the diagnosis of corneal endotheliitis. About 50μ1 of the aqueous was aspirated. Quantitative PCR showed 4.7×103 copies/sample of HSV-DNA, and negative findings for varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, or HHV-7 virus. He was treated by topical and systemic acyclovir, and topical betamethasone. The corneal stromal edema decreased after 4 weeks of treatment and dissolved 3 months later. PCR of aqueous showed no HSV-DNA. Conclusion:Quantitative PCR was useful in the diagnosis and treatment of corneal endotheliitis by HSV. To our best knowledge, this is the first report on quantitative PCR in corneal endotheliitis.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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