ダウン症候群にみられた球状角膜の1例

Keratoglobus in Down's syndrome. Report of a case

　ダウン症候群の33歳女性に両側の球状角膜が併発した。

　本症例は，角膜厚が一様に薄く，円錐状の突出がなく，またFleischer輪を認めず，眼球硬性がきわめて低い等の特徴から，今まで少なからずダウン症候群との合併が報告されている円錐角膜と鑑別された。角膜内皮細胞の観察では，片眼で細胞密度の著しい低下があり，急性水腫の既往が疑われた。

A 33-year-old female presented with clinical manifestations of Down's syndrome and keratog-lobus. The keratoglobus was characterized by bilaterality, very small radius of corneal curvature at less than 5.6 mm, and very deep anterior cham-ber depth at 4.6 and 4.8 mm each. Keratoconus could be ruled out on account of uniform andreduced corneal thickness, very low ocular rigidity and absence of Fleischer's ring in the cornea. The endothelial cell population in the central cornea was normal in the left eye and was reduced in the right. The loss of endothelial cells seemed to be the consequence of an earlier episode of acute hydrops in the right eye.