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Prostaglandins are involved in permeability of blood-aqueous barrier and intraocular pressure following argon laser trabeculoplasty Tadahiko Tsuru 1 , Mitsuru Sawa 1 1Dept of Ophthalmol, Jichi Med Sch pp.1155-1159
Published Date 1988/10/15
DOI https://doi.org/10.11477/mf.1410210527
  • Abstract
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We performed argon laser trabeculoplasty (ALT) in 29 eyes with open angle glaucoma. The cases were evaluated by means of fluoro-photometry as to the permeability of blood-aque-ous barrier after ALT. Topical 0.1 % flurbiprofen (FP) ophthalmic solution was instilled in 12 eyes, 12 subjects, 3 hours before and for 3 consecutive days after ALT. The remaining 17 eyes, 15 subjects, received a vehicle solution as control.

The permeability of blood-aqueous barrier was significantly increased after ALT for 1 to 2 weeks in both groups. The increased permeability was significantly less in FP-treated group than in con-trols during 14 days after ALT. The decrease in outflow pressure was significantly more in control eyes than FP-treated eyes. There was no difference in the rate of transient rise of intraocular pressure within 24 hours after ALT in the two groups. The findings suggest that prostaglandins play a key role in increasing the blood-aqueous barrier and in decreasing the intraocular pressure after ALT.

Rinsho Ganka (Jpn J Chn Ophthalmol) 42(10) : 1155-1159, 1988


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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