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近年増加傾向にある内因性真菌性眼内炎に対する硝子体手術の意義と,この術式を本症のどの時期に行うべきかについて,我々の経験した症例を基に考察した.本症に対する硝子体手術の意義は,①確定診断,②病巣である硝子体ゲルの除去,③全身投与した薬物の眼球内移行促進,そして④硝子体網膜牽引の解除という4点にある.本症の初期例に対しては,まず抗真菌剤の全身投与を行い,速やかに病巣の鎮静化をはかることが肝要である.しかし,眼内病変の遷延化例や,病変の主座が硝子体内に移行しさらに硝子体網膜牽引が生じた症例に対しては,早急に硝子体手術を施行するのが望ましいと考える.さらに全身的合併症のため,抗真菌剤の長期投与が不可能と考えられる症例に対しても,硝子体手術を積極的に考慮すべきと考える.
This paper discusses the indication and efficacy of pars plana vitrectomy for endogenous fungal endophthalmitis, based on our experience in 2 cases. This procedure is beneficial in 4 aspects. It confirms the clinical diagnosis by allowing direct examination of excised vitreous. It removes the vitreous mass in which the fungus is growing. It improves penetration of systemically administeredantifungal agents into the vitreous cavity. It relieves vitreoretinal traction.
During the early phase of the disease, systemic antifungal medication is advocated to treat the involved choroidal and retinal lesions. This medica-tion may fail when the infection involves the vitre-ous. Pars plana vitrectomy is indicated in such cases and also in eyes with vitreoretinal traction. Pars plana vitrectomy is to be considered whenever systemic antifungal medication is not feasible.
Rinsho Ganka (Jpn J Clin Ophthalmol) 42(8) : 941-946, 1988
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