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レーザー前房蛋白・細胞測定装置及びフルオロフォトメトリーにより計画的嚢外摘出術・後房眼内レンズ挿入術の術後炎症についての検討を行った.対象は計画的嚢外摘出術・後房眼内レンズ挿入術を行った38例(老人性白内障37例,外傷性白内障1例)であり,測定対象期間は術後7日間,術6又は7日目にフルオレセインナトリウム1mg/体重kg静注法によるフルオロフォトメトリーを行った.術後,前房蛋白・細胞測定装置により4日以上検査を行い得た症例中フィブリン非析出例18例,析出例10例であった.フィブリン非析出例では術後経過と共に前房蛋白,細胞数共に減少をみた.フィブリン析出例では術翌日析出例2例と外傷性白内障1例を除く7例でフィブリン析出と共に蛋白濃度の上昇を認めた.前房蛋白濃度とフルオロフォトメトリーによる房水/血液フルオレセイン濃度比との間には有意の相関(r=0.603,p=0.000)を認めた.
レーザー前房蛋白・細胞測定装置は術後炎症経過の定量的検討に有用であり,その結果,眼内レンズ挿入術後眼の術後フィブリン析出例では析出に一致して蛋白濃度の上昇がみられた.
We evaluated the postoperative inflammation following extracapsular cataract extraction and posterior chamber intraocular lens implantation. A newly developed laser flare-cell meter was used in the measurement. The series comprised 37 eyes with senile cataract and 1 traumatic one. Preoper-atively, all the eyes received topical prostaglandins biosynthesis inhibitor. Topical steroid was used postoperatively. No systemic steroid was used unless inflammation with fibrinous exudate devel-oped.
We examined 28 eyes for at least 4 days postoper-atively. confirmed uneventful postoperative course in 18 eyes and postoperative inflammation with fibrinous exudate in 10 eyes. Eyes with un-eventful course showed gradual decrease in protein concentration and number of cells in the anterior chamber. Out of 10 eyes with fibrinous exudate, two manifested exudate on the first postoperative day alone and the third happened to be traumatic cata-ract. All the other 7 eyes showed reincrease in protein concentration parallel with the fibrinous exudate.
We performed fluorophotometry on the 6th or 7th postoperative day by injecting 1 mg/kg fluorescein sodium intravenously. We determined the ratio of dye concentration in the aqueous and the plasma ultrafiltrate as index for the blood-aqueous barrier function (Fa/Fp). We found a significant correla-tion between the absolute value for aqueous protein concentration and Fa/Fp (r = 0.603, p= 0.00).
Rinsho Ganka (Jpn J Clin Ophthalmol) 42(6) : 665-668, 1988
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