上皮型角膜ヘルペスに対する抗ウイルス剤phosphonoacetic acid点眼液の治療効果について

Value of phosphonoacetic acid ophthalmic solution for herpetic corneal epithelial lesion

　体重2.5kg雄白色家兎（JW）15羽に，HSV1（HF株，10⁶pfu／ml）ウイルスを塩田変法で接種した．2日後よりIDU,ACV,PAAの治療を1日3回，15日間行い，以下の結論が得られた．

（1） PAA点眼液は，家兎の上皮型角膜ヘルペスに対し有効であった．

（2） IDU,ACV,PAAの治療群では，三者ともに角膜潰瘍は7〜9日で消失した．

（3）充血，眼脂，角膜潰瘍の総合判定からはIDU,ACV,PAAの治療効果は三者ともに同じであった．

We evaluated the effect of phosphonoacetic acid (PAA) ophthalmic solution as applied to experi-mentally produced herpes simplex infection of the cornea.

Fifteen Japanese white rabbits, weighing 2.5 kg, were inoculated with HSV-1 virus, HF strain, in the cornea. We used Shioda's multiple microinoculation technique by gently abrading the anesthetized cor-nea.

Treatment of thus produced superficial herpetic keratitis was started on postinfection day 2 and continued 3 times daily for 15 days, either with topical 5-iodo-2'-deoxyuridine (IDU), acy-cloguanosine (ACV), or PAA.

Topical PAA instillation was generally effective for superficial herpetic keratitis in rabbits. Corneal ulcers disappeared in 7 to 9 days after treatment with IDU, ACV or PAA. When judged with hypere-mia, secretion and corneal ulcer as parameters, IDU, ACV and PAA were judged to be equally effective.

Rinsho Ganka (Jpn J Clin Ophthalmol) 41(6) : 619-623, 1987