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Clinical Value of Acetyl Cysteine Eyedrops for Keratopathies Including Herpes Simplex Keratitis Rikutaro Hinokuma 1 , Hiroyuki Baba 1 , Tadahiko Murata 1 1Department of Ophthalmology, Kumamoto University School of Medicine pp.1381-1385
Published Date 1976/12/15
DOI https://doi.org/10.11477/mf.1410205554
  • Abstract
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The collagenase activity in the cornea is re-portedly increased when corneal ulcers develop and progress. Topically applied collagenase in-hibitors promise to be effective for treatment of corneal ulcers. We applied 3% aqueous so-lution of N-acetyl cysteine, one of collagenase inhibitors, to the treatment of herpes simplex keratitis (11 eyes), corneal ulcers which deve-loped as complication of vernal catarrah (2), keratitis caused by burn (1), parencymatous keratitis (1), corneal erosion caused by chem-ical substance (1), bullous keratitis (1) and keratoconjunctivitis sicca (1). Instillation 6 ti-mes a day resulted in satisfactory beneficial effects in all the cases. The response was pa-rticularly favorable in herpes simplex keratitis. The treatment was also effective for disorders of the corneal stroma without ulcer or epithe-lial defects.


Copyright © 1976, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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