Treatment of central retinal vein occlusion with fibrinolytico-anticoagulant preparations Hideya Uchida 1 , Eriko Yabushita 1 , Shozo Nishida 1 1Dept. of Ophthalmol, Aichi Med Univ pp.477-482
Published Date 1987/5/15
DOI https://doi.org/10.11477/mf.1410210018
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We treated 43 eyes in 43 cases with central retinal vein occlusion by systemic administration of uro-kinase and/or warfarin. we treated 14 cases with a combined use of urokinase. 600,000 IU iv for 2 days with concomitant warfarin. 15 cases with urokinase, 240,000 IU iv for 5 days with warfarin, and 14 cases with urokinase alone.

All the cases treated with urokinase drip infusion showed remarkable increases in fibrinolytic activ-ities, particularly in the group given 600,000 IU urokinase with warfarin. Urokinae drip infusion did not influence the activity of blood coagulationfactors.

Combined use of urokinse and warfarin showed a tendency to inhibit blood coagulation. The duration between onset of therapy and attainment of best visual acuity was the shortest for the group treated with 600,000 IU urokinase com-bined with warfarin. Panretinal photocoagulation exerted a beneficial effects on visual acuity in selected cases.

The findings suggest that a combined systemic therapy with urokinse and warfarin appears to be effective in the treatment of central retinal vein occlusion. Photocoagulation is also an effective adjunct therapy in some cases.

Rinsho Ganka (Jpn J Clin Ophthalmol) 41(5) : 477-482, 1987

Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.


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