内因性ぶどう膜炎発症における免疫複合体の意義—Raji細胞法による検討

Relationship between circulating immune complexes and pathogenesis of endogenous uveitis

　内因性ぶどう膜炎発症と免疫複合体（IC）との関連性をみるために，各種ぶどう膜炎患者の血中ICをRaji細胞法にて測定し，以下の結果をえた．

（1）原因未同定の前部ぶどう膜炎において血中ICが有意に高い値を示した．

（2）ベーチェット病の発作期，原田病の活動期，原因未同定の前部ぶどう膜炎の活動期において血中ICは高い値を示した．

（3）ベーチェット病および原因未同定の前部ぶどう膜炎において高い陽性率を認めた．

We evaluated the circulating immune complexes in patients with various endogenous uveitis includ-ing 62 cases of Behçet's disease, 44 cases of Harada's disease and 25 cases of anterior uveitis of unknown etiology. We employed radioimmunoassay using Raji cells.

The mean value of circulating immune com-plexes was 3.57 μg AHG Eq/ml in healthy controls, 5.80 in Behçet's disease, 4.79 in Harada's disease and 9.85 in anterior uveitis of unknown etiology.The value of immune complexes was significantly high in anterior uveitis of unknown etiology (t= 2.70, p<0.05).

An elevation of immune complex level over the mean normal value+2 s.d. (standard deviation) was obeserved in 10 out of 62 patients with Behcet's disease, 5 out of 44 with Harada's disease and 5 of 25 with anterior uveitis of unknown etiology.

Cases with Behcet's disease, Harada's disease and anterior uveitis of unknown etiology showed higher immune complex levels during acute attacks or active phases than during remissions or inactive phases of the disease.