調節麻痺剤—サイプレジン1％点眼液の屈折検査の為の使用

Diagnostic Use of Cyplegin 1% Eye-drops Cycloplegic for Refraction

緒言

　小児の屈折検査の為には，調節麻痺作用も発現が早く，十分深い調節麻痺効果があり，しかも適当な作用時間の得られる薬の出現が望まれる。

　1952年，Traves　＆　Testaにより合成されたアリル酢酸のアミノアルキル誘導体Cyclopen—tolate hydrochloride （米国薬局方第18版にも収載され，Cyclogylの商品名で米国に於て市販されている）は白色の結晶で水溶性，融点139℃，下記の構造式を示す物質である（第1図）。

A clinical study was conducted to assess the value of Cyplegin (Cyclopentolate hydroch-loride) for the determination of refraction. Cy-plegin (1% solution) was instilled in otherwise normal eyes with wide angle in 42 patients for practical refraction under cycloplegia. Following findings have been obtained.

1. Satisfactory cycloplegic effect set in 45 mi-nutes after instillation and lasted for 4 hours. The residual accommodation one hour after in-stillation averaged 1.95 diopters.

2. The facility of outflow showed a decrease to an average of 49.5% and the intraocular pressure showed a slight rise by an average of 19.3%.