悪性腫瘍患者にみられる網膜神経節細胞層の菲薄化

Thinning of retinal ganglion cell layer in patients with malignancy

要約　目的：悪性腫瘍患者にみられる網膜神経節細胞層（RGCL）と視神経線維層（RNFL）の菲薄化を画像解析した。対象と方法：悪性腫瘍群92名184眼を対象とし，正常眼圧緑内障群34名68眼，健常者群29名58眼を対照とした。悪性腫瘍の内訳は胃癌，食道癌，肝癌，大腸癌，腎癌などであった。画像解析装置は3D OCT-2000を用いた。結果：悪性腫瘍群では96.3％にRGCL菲薄化（健康対照との比較p＜0.01）がみられ，RNFLの菲薄化は58.3％にみられた。健常者群と比較してRGCL厚の平均値は有意な（p＜0.001）減少がみられた。結論：悪性腫瘍群では腫瘍の種類による特異性のないRGCLとRNFL厚の菲薄化がみられた。

Abstract.　Purpose：To report imaging analyses of retinal ganglion cell layer（RGCL）thinning followed by retinal nerve fiber layer（RNFL）thinning in patients with history of malignancy. Subjects and Methods：This study was made on 184 eyes of 92 patients with history of malignancy, included gastric, esophageal, liver, colon, and kidney cancer, etc. The findings were compared with those in 68 eyes of 34 patients with normal tension glaucoma and 58 eyes of 29 healthy controls. The imaging analyses apparatus was 3D OCT-2000. Results：The significance maps showed RGCL thinning in 96.3％ of patients with malignancy. The RNFL thickness around the disc showed thinning in 58.3％ of patients with malignancy. Average values of RGCL thickness showed significant thinning（p＜0.001）compared with healthy control. Conclusion：The cancer nonspecific thinning of RGCL followed by RNFL in patients with history of malignancy was observed.