Rinsho Ganka Volume 64, Issue 9 (September 2010)

Two cases of conjunctiva-corneal intraepithelial neoplasia treated by topical interferon alpha-2b Makiko Matsumoto 1 , Kiyoshi Suzuma 1 , Naoki Imamura 1 , Hirofumi Kinoshita 1 , Tomayoshi Hayashi 2 , Takashi Kitaoka 1 1Dept of Ophthalmol and Vis Sci,Grad Sch of Biomed Sci,Nagasaki Univ 2Dept of Pathol,Nagasaki Univ Hosp pp.1539-1543
Published Date 2010/9/15
DOI https://doi.org/10.11477/mf.1410103337
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Abstract. Purpose:To report 2 cases of intraepithelial neoplasm of the cornea and conjunctiva treated by instillation of interferon alpha-2b. Cases:Two males,aged 72 and 77 years respectively,were referred to us for unilateral tumor of bulbar conjunctiva. Excised tumor was diagnosed with conjunctiva-corneal intraepithelial neoplasia. Both cases started instillation of interferon alpha-2b 4 times daily. There was no recurrence after 3 and 4 months of instillation. The tumor recurred after 2 and 24 months respectively necessitating restart of instillation of interferon alpha-2b. The treatment resulted in suppression of further progression but did not induce regression of the tumor. Conclusion:Conjunctiva-corneal intraepithelial neoplasia was suppressed but failed to regress after instillation of interferon alpha-2b in the present 2 cases.

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64巻9号 (2010年9月)
電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院