Rinsho Ganka Volume 70, Issue 6 (June 2016)
Japanese

Influence of oral kallidinogenase on the retinal blood flow in patients of central retinal vein occlusion Fumito Akiyama 1 , Makiko Matsumoto 1 , Kiyoshi Suzuma 1,2 , Eiko Tsuiki 1 , Azusa Fujikawa 1 , Takashi Kitaoka 1 1Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University 2Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University pp.873-878
Published Date 2016/6/15
DOI https://doi.org/10.11477/mf.1410211838
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Abstract Purpose: To report changes in retinal blow flow after intravitreal anti-VEGF preparations in patients of central retinal vein occlusion treated with or without oral kallidinogenase.

Cases and Methods: This study was made on 56 eyes of 56 patients with central retinal vein occlusion treated by us in the past 64 months. The series comprised 28 males and 28 females. The age averaged 68.7±10.6 years. All the affected eyes showed macular edema. Each case received multiple sessions of intravitreal injection of anti-VEGF. Out of the 56 cases, 26 cases had been receiving peroral kallidinogenase from the referring physician. They received the same treatment after referral to us. The other 30 cases had received no kallidinogenase either from the referring physicians or from us throughout. Laser speckle flowgraphy was used to measure the circulation in major retinal vessels in the disc area. Mean blur rate was used as indicator. Cases were followed up for one year or longer.

Findings: Mean visual acuity improved in all the cases(p<0.01). No difference was present between cases treated by kallidinogenase or not. Mean foveal thickness decreased in all the cases(p<0.01). No difference was present between cases treated by kallidinogenase or not. Retinal circulation improved in all the cases. Improvement averaged 167±73% in cases treated with kallidinogenase and 125±37% without. The difference was significant(p<0.05).

Conclusion: Retinal circulation improved in cases of central retinal vein occlusion treaed with oral kallidinogenase.


Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.

基本情報

03705579.70.6.jpg
臨床眼科
70巻6号 (2016年6月)
電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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