ドルゾラミド点眼薬のプロスタグランジン関連点眼薬への短期追加投与

Short-term hypotensive effect of dorzolamide added to prostaglandin-related topical medication

要約　目的：プロスタグランジン関連点眼薬にドルゾラミドを追加投与したときの効果と安全性の報告。対象と方法：14施設で加療中の広義の原発開放隅角緑内障55例55眼を対象とした。男性26例，女性29例で，年齢は43～88歳，平均71歳である。50例はラタノプロスト，5例はトラボプロストを点眼中で，平均眼圧は16.7±2.4mmHgであった。1％ドルゾラミドを1日3回点眼し，6か月間の経過を追った。結果：ドルゾラミドの追加投与で眼圧は有意に下降した（p＜0.0001）。眼圧下降幅と下降率は，追加投与開始から1か月，3か月，6か月で差がなかった。1例が眼圧上昇，2例が通院中断で脱落した。結論：プロスタグランジン関連点眼薬を使用中の症例に対するドルゾラミドの追加投与により，安全で強い眼圧下降効果が得られた。

Abstract.　Purpose：To report the outcome of topical dorzolamide added to prostaglandin-related medications. Object and Method：This prospective study was made on 55 eyes of 55 patients who were treated for primary open-angle glaucoma in its broad sense in fourteen institutions. The series comprised 26 males and 29 females. The age ranged from 43 to 88 years,average 71 years. Fifty cases were receiving latanoprost and five cases travoprost. The intraocular pressure（IOP）averaged 16.7±2.4 mmHg. Each case started additional instillation of 1％ dorzolamide thrice daily. Cases were followed up for 6 months. Results：IOP decreased significantly after addition of dorzolamide（p＜0.0001）. There was no difference in the amount or rate of IOP decrease at 1,3 and 6 months of treatment. Use of dorzolamide was discontinued in one case due to rise in IOP and in 2 cases who dropped out. Conclusion：Topical dorzolamide added to prostaglandin-related medication showed safe and marked hypotensive effect.