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Comparison of hypotensive effect by timolol XE,brinzolamide and bunazosin as adjunct to latanoprost Hiroshi Kobayashi 1 , Kaori Kobayashi 2 1Dept of Ophthalmol,Kokura Memorial Hosp 2Dept of Ophthalmol,Kurashiki Central Hosp pp.1999-2002
Published Date 2008/12/15
DOI https://doi.org/10.11477/mf.1410102566
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Abstract. Purpose:To compare the hypotensive effect of timolol XE,brinzolamide and bunazosin as adjunct to latanoprost. Cases and Method:This prospective study was made on 45 eyes of 45 patients of open-angle glaucoma that had intraocular pressure(IOP)of 21 mmHg before treatment and that needed further hypotensive effect after topical latanoprost for 6 months or over. Patients were aged 42 to 81 years,average 70 years. IOP before and after latanoprost averaged 22.9 mmHg and 18.0 mmHg respectively. Cases were randomly divided into 3 groups of 15 eyes each. Each group received timolol XE,brinzolamaide or bunazosin for 12 weeks as adjunct to latanoprost. Results:IOP decreased in each group after 12 weeks. The decrease averaged 2.0±0.8 mmHg after timolol XE,2.2±0.7 mmHg after brinzolamide,and 1.4±0.8 mmHg after bunazosin. Hypotensive effect was greater after timolol XE and brinzolamide than bunazosin(p=0.0494 for timolol XE,p=0.00693 for brinzolamide). Conclusion:Instillation of timolol XE,brinzolamide or bunazosin for 12 weeks induces decreased IOP as adjunct to latanoprost. Hypotensive effect is greater after timolol XE or brinzolamide than bunazosin.


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