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Hypotensive effect of unoprostone as adjunct to latanoprost during multiple drug therapy for glaucoma Hiroshi Kobayashi 1 , Ryo Iwakiri 1 , Kaori Kobayashi 1 , Satoshi Okinami 1 1Dept of Ophthalmol,Fac of Med,Saga Univ pp.193-197
Published Date 2004/2/15
DOI https://doi.org/10.11477/mf.1410101038
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 Purpose:To evaluate the hypotensive effect of 0.012%unoprostone when added to latanoprost in multiple drug treatment. Methods:Fifty eyes of 50 patients with primary open-angle glaucoma were enrolled in the study. They had been receiving 0.5%timolol,0.005%latanoprost and 1%dorzolamide for 3months or longer. They were randomly divided into two groups of 25 eyes each. One group received unoprostone adjunctively. The other group continued the medication without unoprostone and served as control. Results:Baseline intraocular pressure(IOP)averaged 19.4±2.5mmHg in unoprostone group and 19.6±2.4mmHg in control group. There was no significant difference between the two values. Eight weeks after start of unoprostone,the IOP averaged 19.1±1.9mmHg in unoprostone group and 19.6±2.4mmHg in control group. There was no significant difference in IOP between both groups up to 8 weeks. In 17 eyes with baseline IOP of 22mmHg or over,the IOP decreased 8 weeks later by 1.3±1.0mmHg in 8 eyes receiving unoprostone and by 0.1±1.0mmHg in 9 control eyes. The difference was significant(p=0.0324).There was no difference in IOP in 33 eyes with baseline IOP of 21mmHg or less. Conclusion:Addition of unoprostone did not induce further ocular hypotension when seen as a whole. Only when the baseline IOP was 22mmHg or over,additional unoprostone induced significant IOP reduction.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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