黄斑浮腫を伴う網膜静脈閉塞症への硝子体手術施行眼に対するベバシズマブ硝子体注入の効果の検討

Effect of intravitreal injection of bevacizumab for retinal vein occlusion with macular edema in eyes after vitrectomy

要約　目的：網膜静脈閉塞症に続発した黄斑浮腫眼に硝子体手術を行い，その後ベバシズマブを硝子体に注入した結果の報告。対象と方法：14例14眼を対象とした。網膜中心静脈閉塞症2眼，網膜静脈分枝閉塞症12眼で，男性9眼，女性5眼であった。14眼中7眼には硝子体手術の既往があった。全例に黄斑浮腫があり，ベバシズマブ1.25mgを硝子体に注入した。視力はlogMARで評価し，0.2以上の変化を有意とした。結果：術後5か月間の観察で，視力は全例で改善または不変であった。初回投与前と投与2週間後で，中心窩厚は12眼で減少し，硝子体手術の既往とは無関係であった。黄斑浮腫は11眼で改善，3眼で不変であり，硝子体手術の既往とは無関係であった。結論：ベバシズマブの硝子体内投与は黄斑浮腫に有効であり，硝子体手術の既往とは無関係である。

Abstract.　Purpose：To report the outcome of intravireal injection of bevacizumab for retinal vein occlusion with macular edema in eyes with or without previous vitrectomy. Cases and Method：This study was made on 14 eyes of 14 patients. Central retinal vein occlusion was present in 2 eyes and branch retinal vein occlusion in 12 eyes. The series comprised 9 males and 5 females. Vitrectomy had been performed on 7 eyes. All the 14 eyes had macular edema. Each eye received intravitreal injection of 1.25 mg bevacizumab. Visual acuity was evaluated as logMAR. Changes by 0.2 or more were regarded as significant. Cases were followed up for 5 months or longer. Results：Visual acuity improved or remained unchanged in all he eyes. Foveal thickness decreased in 12 eyes 2 weeks after treatment. Macular edema improved in 11 eyes and remained unchanged in 3 eyes irrespective of previous vitrectomy. Conclusion：Intravitreal bevacizumab is effective for macular edema in eyes with or without previous vitrectomy.