炭酸脱水酵素阻害点眼薬による視神経乳頭循環への影響

Influence of instillation of carbonic anhydrase inhibitors on the circulation in the optic nerve head

要約　目的：炭酸脱水酵素阻害薬の点眼が視神経乳頭の循環に及ぼす影響の報告。対象と方法：24～56歳の健康な成人10名を対象とした。5名には1％ドルゾラミド，5名には1％ブリンゾラミドを片眼に点眼し，他眼には生理食塩水を点眼して対照とした。乳頭面の動脈，静脈，微小循環系の循環をレーザースペックル法でsquare blur rate（SBR）を指標として，点眼開始前と2週間後に測定した。結果：2週間のドルゾラミド点眼およびブリンゾラミド点眼では，他眼に比較して点眼側で乳頭循環に有意な違いは生じなかった。結論：ドルゾラミドまたはブリンゾラミドの2週間点眼では，健康な成人の視神経乳頭の循環には有意な変化が起こらない。

Abstract.　Purpose：To report the effect of instillation of carbonic anhydrase inhibitors on the circulation of optic nerve head in healthy adults. Cases and Method：This study was made on 10 healthy humans between 24 and 56 years of age. Five cases received daily instillation of 1％ dorzolamide in one eye. The other 5 cases received daily instillation of 1％ brinzolamide. The fellow eyes received physiological saline and served as control. Laser speckle method was used to quantitate the blood flow velocity in the artery, vein and microcirculation in the optic nerve head. Square blur rate（SBR）served as indicator of blood flow velocity before and after 2 weeks of instillation. Results：There was no significant difference in the circulation of optic nerve head before and after 2 weeks of instillation of dorzolamide or brinzolamide when compared with the fellow eye. Conclusion：Daily instillation of dorzolamide or brinzolamide for 2 weeks does not significantly influence the circulation in the optic nerve head in healthy adults when measured by laser speckle method.