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目的:眼球表面疾患に対する羊膜移植術の結果報告。対象:2004年までの7年間に羊膜移植術を行った63例71眼を対象とした。内訳は,翼状片33眼,角膜穿孔7眼を含む角膜潰瘍13眼,角結膜腫瘍9眼,瘢痕性角結膜症6眼,遷延性角膜上皮欠損3眼,そのほか7眼である。58眼では上皮再生促進,13眼では角膜潰瘍による実質充填を目的とした。結果:58眼中54眼(93%)で上皮が再生した。13眼中9眼(69%)で角膜実質充填が成功し,角膜が穿孔した7眼中2眼で再穿孔した。羊膜による感染が2眼に生じた。結論:角結膜上皮の再生促進に羊膜移植術は有効であるが,羊膜による感染と角膜の再穿孔に注意が必要である。
Purpose:To report the outcome of amniotic membrane transplantation for ocular surface diseases. Cases:This retrospective study comprised 71 eyes of 63 patients that received amniotic membrane transplantation during 7 years through 2004. The series comprised pterygium 33 eyes, corneal ulcer 13 eyes including 7 eyes of corneal perforation, corneal or conjunctival tumor 9 eyes, cicatricial keratoconjunctivitis 6 eyes, protracted corneal epithelial defect 3 eyes and other 7 eyes. Amniotic membrane was transplanted to promote epithelialization in 58 eyes and to fill corneal defect in 13 eyes. Results:The ocular surface became epithelialized in 54 out of 58 eyes(93%). Corneal defect disappeared in 9 out of 13 eyes(69%). The cornea reperforated in 2 out of 7 eyes. Infection due to amniotic membrane developed in 2 eyes. Conclusion:Amniotic membrane transplantation is useful for ocular surface diseases. Infection and corneal reperforation need due attention.
Rinsho Ganka(Jpn J Clin Ophthalmol)60(8):1443-1447, 2006
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