糖尿病網膜症のpigment epithelium-derived factorと血管内皮細胞増殖因子

Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy

要約　Pigment epithelium derived factor（PEDF）は強力な血管新生抑制作用が報告されている。増殖型糖尿病網膜症（PDR）21例23眼，非増殖型糖尿病網膜症（NPDR）2例3眼の硝子体内PEDF濃度および血管内皮細胞増殖因子（VEGF）濃度をELISAで測定した。PDRのPEDF濃度は平均0.81μg/mlと低値を示し，NPDRは2.44μg/mlと高値であった。一方，硝子体内VEGF濃度はPDRで平均2,090pg/ml，NPDRは平均15pg/mlであった。PDRは硝子体内PEDF濃度が低く，PEDFによる血管新生抑制効果に乏しいと思われた。

Abstract.　Pigment epithelium-derived factor（PEDF）has been claimed to be a potent inhibitor of ocular angiogenesis. Using enzyme-linked immunosorbent assay（ELISA）,we quantitated the intraviteal levels of PEDF and vascular endothelial growth factor（VEGF）in patients of diabetic retinopathy. The series comprised 23 eyes of proliferative diabetic retinopathy（PDR）and 3 eyes of nonproliferative one（NPDR）. Vitreous specimen from 11 eyes of idiopathic macular hole served as control. The concentration of PEDF averaged 1.58μg/ml in the control,0.81μg/ml in PDR,and 2.44μg/ml in NPDR. There was a significant difference between control and PDR（p＝0.005）and between PDR and NPDR（p＝0.006）. The concentration of VEGF was not detectable in the control,averaged 2,090pg/ml in PDR and 15pg/ml in NPDR.There was a significant difference between control and PDR（p＝0.005）. The findings show that lower levels of PEDF may be related to angiogenesis in diabetic retinopathy resulting in PDR.