Four cases of conjunctival intraepithelial neoplasia treated by excision and amniotic membrane transplantation Noboru Arimura 1 , Shozo Sonoda 1 , Eisuke Uchino 1 , Kayoko Hayami 1 , Taiji Sakamoto 1 1Dept of Ophthalmol,Kagoshima Univ Grad Sch of Med and Dent Sci pp.1899-1903
Published Date 2005/11/15
DOI https://doi.org/10.11477/mf.1410100250
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We treated 4 eyes of 4 patients of conjunctival intraepithelial neoplasia(CIN). The tumor developed in the bulbar conjunctiva adjacent to the limbus in all the eyes. The series comprised 3 males and 1 female. Two cases were primary and the other two were recurrent CIN. Their ages ranged from 53 to 72 years,average 64 years. The diagnosis was confirmed by histopathologic studies in all the cases. After demarcation of the lesion by rose bengal,the tumor was resected including the surrounding healthy conjunctiva. The conjunctival defect was covered by freeze-preserved amniotic membrane followed by 0.04% mitomycin C. The lesion was cryocoagulated in 2 recurrent cases. There was no recurrence or excessive scarring during the follow up for 5 to 38 months,average 20 months. These cases illustrate that CIN may be cured by complete excision with transplantation of amniotic membrane.

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