Histopathological Problems of ‘Dysplasia' and ‘Intraepithelial Neoplasia'of the Esophagus Yasuo Ohkura 1 1Department of Pathology, Kyorin University School of Medicine, Tokyo Keyword: dysplasia , 異形成 , intraepithelial neoplasia , 上皮内腫瘍 , 病理診断 pp.587-591
Published Date 2011/5/24
DOI https://doi.org/10.11477/mf.1403102218
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 In an attempt of resolve confusion surrounding the term‘dysplasia', the term‘intraepithelial neoplasia'is adopted in WHO classification. The term‘intraepithelial neoplasia'shows a disease entity of benign epithelial tumor, but no different essentially from the term‘dysplasia'. There are many cases of in situ carcinoma in which cancer cells occupy the lower half of the epithelium. They are categorized low-grade intraepithelial neoplasia by the rule of subclassification, but they should be diagnosed high-grade intraepithelial neoplasia which contain in situ carcinoma. There is thus a contradiction in the subclassification of intraepithelial neoplasia. Benign epithelial tumors are very few in the esophagus and most cases which are diagnosed as intraepithelial neoplasia are lesions which are suspected of being in situ carcinomas. So it is necessary to establish diagnostic criteria of “in situ carcinoma” to make clear the concept for intraepithelial neoplasia.

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