Differential Diagnosis Between Squamous Cell Carcinoma in situ and Intraepithelial Neoplasia of the Esophagus Takashi Yao 1 , Hidenae Nakayama 1 , Yimamu Abudukade 1 , Hiroya Ueyama 1 , Shiho Iwamoto 1 , Takuo Hayashi 1 , Hiroyuki Mitomi 1 1Department of Human Pathology, Juntendo University School of Medicine, Tokyo Keyword: esophageal carcinoma , carcinoma in situ , intraepithelial neoplasia , dysplasia pp.1741-1748
Published Date 2009/10/25
DOI https://doi.org/10.11477/mf.1403101782
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 The classification of dysplasia was deleted in the Japanese classification of esophageal cancer(The 10th edition). Instead, intraepithelial neoplasia(IN)has been newly introduced. The intraepithelial tumor is classified into carcinoma in situ(CIS)and IN according to the new classification, but, this idea has not become popular yet. When the atypical epithelium is recognized as neoplasia, the lesion can be categolized into CIS or IN by the degree of atypia. The presence of an oblique line is the most important feature in diagnosis of neoplasia.

 The lesion can be clearly categorized into CIS and IN according to the new classification compared with the previous one using the vague term “dysplasia”. On the other hand, the new classification involves some problems because of different diagnostic criteria between pathologists. In order to solve them, the factors for progression of intraepithelial tumor should be analyzed in association with the histological features.

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