The Effects of Mild Hypothermia on Expression of Stress Protein (HSP72) after Experimental Brain Injury Michio Nakamura 1,2 , Hirokazu Tanno 1 , Kazumasa Fukuda 1 , Akira Yamaura 1 1Department of Neurological surgery, Chiba University School of medicine Keyword: experimental brain injury , hypothermia , heat shock protein , brain protection pp.484-490
Published Date 1995/5/1
DOI https://doi.org/10.11477/mf.1406900789
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Recent studies have demonstrated that mild hypothermia protects brain from ischemic insults. In the present study, we investigated the effects of mild hypothermia on stress responses of the neurons and glia after experimental brain injury. We evaluated the immunocytochemical expression of 72kDa molecular weight heat shock protein (HSP72) as a marker of cellular injury.

Adult male Sprague-Dawley rats were subjected to a lateral fluid percussive injury. After injury the animals were divided into two groups (normother-mic and hypothermic groups).

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