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The Expression of Granulocyte Colony-Stimulating Factor in Malignant Gliomas Tetsuro Kikuchi 1 , Toshiaki Abe 1 1Department of Neurosurgery, The Jikei University School of Medicine Keyword: granulocyte-colony stimulating factor , glioma , RT-PCR , ELISA pp.971-975
Published Date 1994/10/1
DOI https://doi.org/10.11477/mf.1406900699
  • Abstract
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In this study, we investigated the expression of granulocyte colony-stimulating factor (G-CSF), G-CSF mRNA, G-CSF receptor mRNA in glioma cell lines, G-CSF in glioma cyst fluids, and the effect of recombinant G-CSF on the proliferation of glioma cells. First, to determine whether G-CSF is pro-duced by glioma cells, we analyzed for the presence of G-CSF by ELISA in supernatants from glioma cell lines. G-CSF was detected in six of fourteen glioma cell lines constitutively, and, after stimula-tion with tumor necrosis factor-α (TNF-α), G-CSF was detected in four of eight cell lines which did not produce G-CSF constitutively.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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