雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

CHANGES OF MONOAMINE NEUROTRANSMITTER METABOLISM IN BRAIN ISCHEMIA MEASURED BY IN VIVO VOLTAMMETRY Koichiro Ogura 1,2 , Masato Shibuya 1 , Masahiko Kanamori 1 , Yoshio Suzuki 1 , Ichiro Ikegaki 1 , Tsutomu Harada 1 , Tomihisa Okasa 1 , Chiharu Tanoi 1 , Naoki Kageyama 1 1Department of Neurosurgery, Nagoya University School of Medicine pp.87-93
Published Date 1988/1/1
DOI https://doi.org/10.11477/mf.1406206043
  • Abstract
  • Look Inside

A preliminary work with in vivo voltammetry (IVV) in the ischemic brain had been performed by the authors in rats after cardiac arrest, which showed that the IVV system is useful to investi-gate ischemic brain. In the present report, IVV was applied to ischemic brain by 4-vessel occlu-sion in rat and changes in dopamine and serotonine metabolism were investigated by measuring peak 2 (3, 4-dihydroxyphenylacetic acid, DOPAC) and peak 3 (5-hydroxyindoleacetic acid, 5-HIAA) in the striatum. The change of cerebral blood flow (CBF) were also assessed by a temperature-controlled thermoelectrical method in the striatum of the same model.

The heights of peaks 2 and 3 were significantly increased to 600-900% and 200-300% respectively in the striatum during 30 minutes of 4-vessel occlusion. The increase of each peak was maximum at 10 minutes after occlusion. These changes may reflect that release of monoamine neurotransmit-ters is increased by the ischemia and outword transport of their metabolites are disturbed. On the other hand, after reperfusion by release of carotid occlusion, the heights of peaks 2 and 3 rapidly decreased below the control values, there-after, peaks 2 and 3 gradually increased to overcontrol values at 180-210 minutes after reperfusion. rCBF in the striatum decreased to almost 0 ml/ 100 g/min during 4-vessel occlusion ischemia and increased to over control values transiently for 30 minutes after reperfusion, followed by gradual decrease for about 240 minutes.

Since monoamine neurotransmitters are knownto have various effects on cerebral metabolism and CBF, their disorders may contribute to the change of CBF and the developement of postische-mic brain damage. Thus in vivo voltammetry can be usteful for the investigation of pathophysiology of brain ischemia.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

関連文献

もっと見る

文献を共有