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OPSOCLONUS-POLYMYOCLONIA SYNDROME SUPPRESSED WITH RESERPINE Yasuhiro Harada 1 , Hiroshi Ishimitsu 1 , Ken Nishimoto 1 , Ichiro Miyata 1 , Nobuhiko Matsumi 1 1Department of Neurosurgery, Iwakuni National Hospital pp.359-362
Published Date 1986/4/1
DOI https://doi.org/10.11477/mf.1406205692
  • Abstract
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A 38-year-old man was admitted to Iwakuni National Hospital on July 6, 1978, with the com-plaints of difficulty seeing and walking. Two weeks before admission, he first experienced dizziness and it slowly progressed to uncontrollable tremor-like movements of the whole body. On admission, he was alert, oriented and afebrile. He had not experienced nausea, vomiting nor headache. He showed irregular horizontal oscillations of the eyes. Electronystagmographic study showed that this jerky eye movement appeared especially with changes of fixation of the eyes. It was also record-ed during conjugate eye movement, and while he closed his eyes. He was ataxic, unable to walk, but no other abnormalities in cerebellar functions were observed. Spinal tap was performed and yielded watery clear cerebrospinal fluid containing 9/mm3 mononuclear cells. Clonazepam was given, 1. 5 mg per day, for three days followed by doses of 3 mg per day. Improvement in walking was observed one week after starting the medication, when reserpine was started at a dose of 1 mg per day and increased to a dose of 1. 5 mg per day in three days. One week after starting reserpine, opsoclonus improved markedly and he became able to read again. He was discharged home on Sep-tember 3, 1978.

Six months after admission, reserpine was de-creased to 0.5 mg per day. Difficulty in reading developed within a month. Reserpine was given 1.0 mg per day and the doses was continuously given for next three months. One year after admis-sion, he is back to his former occupation without medication. He complains of slight difficulty in reading for more than an hour, and in watching TV.

Thirty cases of opsoclonus-polymyoclonia synd-rome due to infection or of unknown etiology were reported in Japan. Corticosteroids or ACTH was recommended as an effective therapy. In the recent literature, clonazepam and TRH were also considered effective for this syndrome. although the latter shows its effect only for limited duration. Effectiveness of reserpine in this syndrome was not found in the literature. Reserpine produces long-lasting depletion of catecholamines. The pres-ent case supports the possibility that this syn-drome is induced by an excessive storage of catecholamines as some authors indicate.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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