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CEREBRAL HEMODYNAMICS IN CHRONIC-HYPDXIC HYPDXIA Koichi Aritake 1 , Hans-Michael Mayer 2 , Emanuel Fritschka 2 , Jorg Cervós-Navarro 2 , Kintomo Takakura 1 1Department of Neurosurgery, University of Tokyo Hospital 2Institute of Neuropathology, Free University of Berlin pp.363-369
Published Date 1986/4/1
DOI https://doi.org/10.11477/mf.1406205693
  • Abstract
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The effects of chronic-hypoxic hypoxia on ce-rebral blood flow and its regulating mechanisms were investigated by means of intracardiac injec-ion of radioactively labelled microspheres. In a gas chamber designed and constructed for the purpose, adult cats were exposed to stepwise decreasing inspiratory oxygen concentrations (for 4.5 months with a final O2 concentration of 8 vol%). Using animals adapted to hypoxic hypoxia, responsiveness of cerebral blood flow either to alterations in sys-temic arterial pressure (SAP) or to alterations in arterial blood oxygen tension (PaO2) were assessed. Flow measurement was done under three different conditions : normoxic normotension (PaO2>100 mmHg ; SAP>100 mmHg), hypoxic normotension (PaO2= 30 mmHg ; SAP >100 mmHg), or normoxic hypotension (PaO2> 100 mmHg ; SAP= 60 mmHg).

Hematocrit values continuously increased to 56 % during the process of adaptation to hypoxia. There was also a remarkable increase in cardiac output of hypoxia-adapted animals subjected to hypoxia and to normoxia. Chronic-hypoxic hypoxia led to increased cerebral blood flow, which per-sisted even when animals were returned to normo-xia. Under hemorrhagic hypotension, cerebral blood flow fell significantly in animals adapted to chronic-hypoxic hypoxia but did not fall short of the absolute values in controls. The relative reduc-tion in cerebral blood flow might be attributable to the decrease in cardiac output and to altered blood viscosity. This implied that, even in animals subjected to long-standing graded hypoxic hypoxia, autorgulatory capacity might be partly preserved.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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