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BRAIN TISSUE DAMAGE IN CONGENITAL HYDROCEPHALUS OF THE INBRED RAT, LEW/Jms:INTRACEREBRAL CAVITY FORMATION Tohru Okuyama 1 , Kazuo Hashi 1 , Satoshi Sasaki 2 , Katsuko Sudoh 3 1Department of Neurosurgery, Sapporo Medical College 2Department of Veterinary Physiology, Obihiro University of Agriculture and Veterinary Medicine 3Institute of Medical Science, University of Tokyo pp.1053-1057
Published Date 1985/11/1
DOI https://doi.org/10.11477/mf.1406205607
  • Abstract
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Brain tissue damage in congenital hydrocephalic rat (LEW/Jms) was studied in the aspects of the hydrocephalic brain edema and the changes of the vascular apparatus. The characteristic findings in this study were the changes of the small blood vessels and the intracerebral cavity formation.

In the acute stage of hydrocephalus (2 to 5 days after birth), spongy appearance and necrosisof the brain edema were observed in the periven-tricular white matter. The stenotic or obstructive vascular changes were located in connection with the hydrocephalic brain tissue. In this stage, the intracerebral cavity was formed particularly in the periventricular edematous white matter result-ing in a thinning of the occipital lobes.

In the late stage of hydrocephalus (9 to 15 days after birth), the lateral ventricles were severely dilated, and a markedly dilatated intracerebral cavity was observed in the periventricular white matter. The edematous area was observed adjacent to the dilated lateral ventricles or the intracere-bral cavity. In the late stage, the number of small vessels filled with carbon black decreased in the area of the CSF edema when compared to the acute stage, and many obstructive blood vessels were observed in the same area. Moreover, dila-tated blood vessels without carbon black were observed in the border zone between the normal and the edematous area adjacent to the intra-cerebral cavity.

These vascular changes may occur by the ac-cumulation of the CSF as well as the mechanical compression, and consequently lead to the micro-circulatory disturbance. These microcirculatory disturbances may contribute to the intracerebral cavity formation with the accumulation of the CSF in the extracellular space.

The thinning of the brain tissue observed in congenital hydrocephalus may be the result of the intracerebral cavity formation that could occur only in the immature brain tissue.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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